Marboken
Combination of 40 mg/ml Marbofloxacin + 60 mg/ml Ketoprofen for the treatment of bacterial infections in cattle and pigs caused by organisms sensitive to marbofloxacin.
Marboken is indicated for the treatment of respiratory, gastrointestinal and urinary tract diseases, skin and soft tissues infections, accompanied by pain syndrome, inflammation or fever; colibacillosis, pasteurellosis, salmonellosis, mycoplasmosis, chlamydiosis, staphylococcosis, erysipelas, MMA (Metritis-Mastitis-Agalactia Syndrome) in sows and bovine mastitis.
DOSAGE AND ADMINISTRATION
For intramuscular injection once daily for 3 consecutive days.
- Cattle, pigs: 0,5 ml per 10 kg body weight (equivalent to 2 mg of marbofloxacin and 3 mg of ketoprofen per kg body weight).
PHARMACOLOGICAL PROPERTIES
The veterinary medicinal product provides broad-spectrum bactericidal action against Gram-positive and Gram-negative bacteria, including Escherichia coli, Salmonella spp., Enterobacter spp., Serratia spp., Morganella morganii, Proteus spp., Klebsiella spp., Shigella spp., Pasteurella spp., Haemophilus spp., Actinobacillus pleuropneumoniae, Moraxella spp., Pseudomonas spp., Brucella spp., Staphylococcus spp., Streptococcus spp., as well as Mycoplasma spp., Chlamydia spp., Rickettsia spp.
Ketoprofen is a non-steroidal anti-inflammatory drug, propionic acid derivative. It provides a pronounced analgesic action, as well as moderate anti-inflammatory and anti-pyretic effect.
Following intramuscular administration, marbofloxacin is rapidly absorbed and extensively distributed to most tissues and organs of the body reaching peak blood concentrations in 30-90 minutes and remains within the therapeutic range for 48 hours. Its bioavailability is close to 100%. It is weakly bound to plasma proteins (less than 10% in pigs, and 30% in cattle). Marbofloxacin has an initial half-life of 5-9 hours in calves and 8-10 hours in pigs. Following intramuscular administration, ketoprofen is rapidly absorbed and extensively distributed to blood and most organs of the body reaching peak blood concentrations in 30-40 minutes. Ketoprofen binds extensively to plasma proteins (>98%). It reaches high concentrations in inflamed tissue. Ketoprofen undergoes metabolism in the liver via conjugation with glucuronic acid (glucuronidation). It has an initial half-life of 2 hours. Ketoprofen is excreted mainly in the urine.
The veterinary medicinal product is eliminated mainly via the urine (80-90%) and faeces.
CONTRAINDICATIONS
Do not use in the case of known hypersensitivity to the active substances.
Do not use in animals suffering from severe hepatic, renal and central nervous system disorders.
WITHDRAWAL PERIODS
Cattle: Meat: 8 days. Milk: 72 hours.
Pigs: Meat: 9 days.
STORAGE CONDITIONS AND SHELF LIFE
Store in the original package between 5°C to 25°C, protected from light and moisture.
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the container: 28 days (aseptic precautions should be observed).
Do not use this veterinary product after the expiry date which is stated on the label.
Keep out of the reach and sight of children.
DOSAGE AND ADMINISTRATION
For intramuscular injection once daily for 3 consecutive days.
- Cattle, pigs: 0,5 ml per 10 kg body weight (equivalent to 2 mg of marbofloxacin and 3 mg of ketoprofen per kg body weight).
PHARMACOLOGICAL PROPERTIES
The veterinary medicinal product provides broad-spectrum bactericidal action against Gram-positive and Gram-negative bacteria, including Escherichia coli, Salmonella spp., Enterobacter spp., Serratia spp., Morganella morganii, Proteus spp., Klebsiella spp., Shigella spp., Pasteurella spp., Haemophilus spp., Actinobacillus pleuropneumoniae, Moraxella spp., Pseudomonas spp., Brucella spp., Staphylococcus spp., Streptococcus spp., as well as Mycoplasma spp., Chlamydia spp., Rickettsia spp.
Ketoprofen is a non-steroidal anti-inflammatory drug, propionic acid derivative. It provides a pronounced analgesic action, as well as moderate anti-inflammatory and anti-pyretic effect.
Following intramuscular administration, marbofloxacin is rapidly absorbed and extensively distributed to most tissues and organs of the body reaching peak blood concentrations in 30-90 minutes and remains within the therapeutic range for 48 hours. Its bioavailability is close to 100%. It is weakly bound to plasma proteins (less than 10% in pigs, and 30% in cattle). Marbofloxacin has an initial half-life of 5-9 hours in calves and 8-10 hours in pigs. Following intramuscular administration, ketoprofen is rapidly absorbed and extensively distributed to blood and most organs of the body reaching peak blood concentrations in 30-40 minutes. Ketoprofen binds extensively to plasma proteins (>98%). It reaches high concentrations in inflamed tissue. Ketoprofen undergoes metabolism in the liver via conjugation with glucuronic acid (glucuronidation). It has an initial half-life of 2 hours. Ketoprofen is excreted mainly in the urine.
The veterinary medicinal product is eliminated mainly via the urine (80-90%) and faeces.
CONTRAINDICATIONS
Do not use in the case of known hypersensitivity to the active substances.
Do not use in animals suffering from severe hepatic, renal and central nervous system disorders.
WITHDRAWAL PERIODS
Cattle: Meat: 8 days. Milk: 72 hours.
Pigs: Meat: 9 days.
STORAGE CONDITIONS AND SHELF LIFE
Store in the original package between 5°C to 25°C, protected from light and moisture.
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the container: 28 days (aseptic precautions should be observed).
Do not use this veterinary product after the expiry date which is stated on the label.
Keep out of the reach and sight of children.
